Digestive: Calcium is the primary mineral of bone formation. It is best absorbed in an acidic environment, but due to digestive dysfunction, most people suffer from a lack of acidity in the stomach that impedes calcium. Examples of digestive dysfunction would include hydrochloric acid deficiencies from B vitamin and zinc deficiencies, bacterial infections of the stomach such as h. pylori, and stress, which inhibits hydrochloric acid production. You immune system is designed to both protect us from invading organisms and repair worn out cells. If your immune system is focused on fighting infections or maintaining mucosal barrier function, it is less able to carry out its other basic functions, including repair of bone. Bone is dynamic structure and on a daily basis is being broken down and replaces: so much so that every seven years, your entire skeletal structure is torn down and rebuilt.
Detoxification: High levels of mercury, lead and other heavy metals directly interfere with bone strength. These toxic metals lead to leaching of calcium and magnesium out of bone as the calcium and magnesium attempt to chelate, or pull out heavy metals. The toxic heavy metal lead is actually stored in bone tissue, which leads to further weakening of the bone structure
(All content above has been reproduced with permission from Dr. Daniel Kalish, D.C., Functional Medicine Practitioner, http://www.clarysageorganics.com